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Antonio Baines
Assistant Professor and Adjunct Faculty

Tel: 919 530-6542
Fax: 919 530-7773
Email: abaines@nccu.edu




  • CV
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Cancerous Cells
Modified from Hruban et al. (2000)      Artwork by Jennifer Parsons-Brumbaugh

Research Statement

          Pancreatic cancer is the 4th most common cause of cancer deaths in the United States. Due to the aggressive nature of this cancer and the lack of biomarkers for early detection, the incidence and mortality rates for pancreatic cancer are nearly equivalent. The presence of oncogenically mutated K-Ras in 90% of human pancreatic ductal adenocarcinomas (PDAC) strongly suggests a critical role for this genetic mutation in the development of this disease. Despite intensive effort, disappointingly, to date no anti-Ras therapies have successfully reached the clinic. 

          The overall focus of our cancer biology research program is to identify and validate the role of novel molecular targets in the development and progression of normal cells transforming into cancer cells of the pancreas. A recent study identified upregulation of the Pim-1 serine/threonine kinase in Ras-mediated transformation of human pancreatic ductal epithelial cells. A second study identified upregulation of the related Pim-3 in PDAC cell lines and patient samples. We hypothesize that inhibition of Pim function will be an effective approach for antagonizing the aberrant growth of pancreatic carcinoma. To test this hypothesis, we will determine the contribution of upregulated Pim kinase genes in aberrant growth transformation of pancreatic cancer. Results from these studies will allow us to critically validate these kinases as novel therapeutic targets for PDAC treatment.

 

Postdoctoral Fellows
-        Dr. Dapeng Xu
-        Dr. Vijaya Nandiwada

Graduate Students
-        Michael Cobb
-        Dana Austin
-        Naima Stennett

Undergraduate Students
-        Aurora Baker
-        Kala Nwachukwu
-        Preston Newby

Publications by Antonio T Baines

Xu, D., Allsop, S., Witherspoon, S.M., Snider, J.L., Yeh, J.J., Fiordalisi, J.J., White, C.D., Williams, D., Cox, A.D., and Baines, A.T. (2011) The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells. Carcinogenesis, 32:4, 488-495.

Rybarczyk, B. J., Baines, A.T., McVey, M., Thompson, J.T., and Wilkins, H. "A Case-based Approach Increases Student Learning Outcomes and Comprehension of Cellular Respiration Concepts", Biochemistry and Molecular Biology Education, Vol. 35, No. 3, pp. 181 -186, 2007.

Lim, K.-H., Baines, A.T., Fiordalisi, J.J., Shipitsin, M., Feig, L.A., Cox, A.D., Der, C.J., and Counter, C.M.: Activation of RalA is critical for Ras-induced tumorigenesis of human cells. Cancer Cell 7:533-545, 2005.

Baines, A.T., Lim, K.-H., Shields, J.M., Lambert, J.M., Counter, C.M., Der, C.J., and Cox, A.D.: Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and Ras effector expression in human tumor cell growth. Methods in Enzymology. Vol. 407, pp. 556-74, 2005.

Baines, A., Taylor-Parker, M., Goulet, A.-C., Renaud, C., Gerner, E.W., and Nelson, M.A.: Selenomethionine inhibits growth and suppresses cyclooxygenase-2 (COX-2) protein expression in human colon cancer cell lines.Cancer Biology and Therapy1(4):370-4, 2002.

 

Cancer Research
Cardiovascular-Metabolic Research
Neuroscience Research
Nutrition Research
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Calendar Of Events


For nearly 100 years, NCCU has had a rich history of creating programs which foster academic development and achievement and the JLC-BBRI is one of our most innovative research initiatives to date. Since 1998, it has strengthened undergraduate science education and focused its research on health issues that disproportionately affect African Americans. As the JLC-BBRI continues to address the health research and training needs of underserved minority groups, it is our hope that the information and research it generates will support the improvement of the health of the minority community, while at the same time providing students with viable skills in biotechnology and broader access to careers in the biomedical sciences.

The mission of BBRI is to conduct research focused on health issues that disproportionately affect African Americans and other minority groups and to provide students with research training and experiences that will enhance access to careers in the biomedical sciences.

2011
BBRI Nutrition Research Program of the North Carolina Central University has a collaborative research grant with Appalachian State University to study Chia seed using the zebrafish model at the North Carolina Research Campus in Kannapolis. In addition, a funded collaborative research agreement was established with UNC Chapel Hill
to study the dietary choline using the zebrafish model.

2011
BBRI Nutrition Research Program of the North Carolina Central University recruited a new cancer research faculty at the North Carolina Research Campus to start a program on dietary and hormonal modulation of breast cancer risks.
The research is funded by a grant from American Cancer Society to study phytoestrogens
and erbB-2 mediated breast carcinogenesis.

2010
BBRI Nutrition Research Program of the North Carolina Central University and NC A&T State University filed the first joint patent originated from the zebrafish research at the North Carolina Research Campus for an innovative treatment to target anemia market.

2009
BBRI Nutrition Research Program of the North Carolina Central University was awarded a Technology Research Grant from the North Carolina Biotechnology Center to develop a zebrafish model for high-throughput drug discovery at the North Carolina Research Campus in Kannapolis.

2008
BBRI Nutrition Research Program of the North Carolina Central University became one of the six university-partners moving into the private-public venture of the North Carolina Research Campus in Kannapolis, a world class research hub where collaborative science will lead the charge for great discoveries in nutrition,
health and biotechnology research.

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